Fig. 4

Strategy shift performance in the Morris water maze. A significant effect of genotype was observed when assessing latency to find the hidden platform (a). A lack of accurate learning and memory in TG rats was also reflected in TG rats exhibiting significantly less “direct swim” patterns (DIM) during the learning of the novel platform location on day 2 (b). WT animals increased the use of a search strategy from day 1 to day 2, while TG rats exhibited a decrease in the chaining search strategy (c)