Fig. 6

Total microglia analysis. IBA-1 positive microglia were assessed in 3 months (a), 15 months (b), and 19 months (c) WT and TG rats. Higher magnification insets are from the (i) corpus callosum, (ii) internal capsule, and (iii) cerebral cortex. Quantification shows TG rats have increased IBA-1 positive microglia in the internal capsule at 15 and 19 months of age (d), but no increased in IBA-1 positive microglia within the corpus callosum (e) or cerebral cortex (f). An asterisk indicates statistical significance between WT and TG rats, (p < 0.05, two-way ANOVA, Tukey’s post hoc test, n values indicated within bars on graphs)