Fig. 7

Cortical histopathology. Photomicrographs of cortical tissue sections from rats at different ages stained with OX-6 for activated microglia (A). Rating scores of OX-6 positive signal revealed a slight increase in cortical signal from 15 to 19 months of age, but no statistically significant genotype differences (B, rating score exemplified in B′). Photomicrographs of medial (left) and lateral (right) cortex sections stained for NeuN positive neurons (C). No genotype difference or neuronal loss was observed after quantification of NeuN signal (D). Statistical analysis was performed using a two-way ANOVA