TY - JOUR AU - Breuer, Johanna AU - Korpos, Eva AU - Hannocks, Melanie-Jane AU - Schneider-Hohendorf, Tilman AU - Song, Jian AU - Zondler, Lisa AU - Herich, Sebastian AU - Flanagan, Ken AU - Korn, Thomas AU - Zarbock, Alexander AU - Kuhlmann, Tanja AU - Sorokin, Lydia AU - Wiendl, Heinz AU - Schwab, Nicholas PY - 2018 DA - 2018/08/22 TI - Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus JO - Journal of Neuroinflammation SP - 236 VL - 15 IS - 1 AB - Very late antigen 4 (VLA-4; integrin α4β1) is critical for transmigration of T helper (TH) 1 cells into the central nervous system (CNS) under inflammatory conditions such as multiple sclerosis (MS). We have previously shown that VLA-4 and melanoma cell adhesion molecule (MCAM) are important for trans-endothelial migration of human TH17 cells in vitro and here investigate their contribution to pathogenic CNS inflammation. SN - 1742-2094 UR - https://doi.org/10.1186/s12974-018-1276-4 DO - 10.1186/s12974-018-1276-4 ID - Breuer2018 ER -