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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

Fig. 5

The main source of NLRP3 inflammasomes expressed in PC12 or bEnd3 cells in transwell co-culture system was from their own productions. a The expression levels of NLRP3, ASC, pro-caspase-1, and cleaved caspase-1 in PC12 and bEnd3 cells in different groups, as measured by western blot. OGD/R treatment in isolated cultures or transwell co-cultures was conducted at 24 h after siRNA transfection in PC12 or bEnd3 cells. b The changes of NLRP3, ASC, and cleaved caspase-1 in PC12 cells among the different groups, as measured by western blot. c The changes of NLRP3, ASC, and cleaved caspase-1 in bEnd3 cells among the different groups, as measured by western blot. *p < 0.05, **p < 0.01. OGD/R: oxygen-glucose deprivation/reoxygenation. The OGD continued for 4 h, followed by reoxygenation

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