Fig. 1

Schematic timeline of the experimental designs. Mice were given doxycycline with oral (Dox; 1% in drinking water) per day from E7.5 to the end of experiment. Open-field test (OFT), amphetamine-induced hyperactivity (AIH), elevated plus-maze (EPM), forced swimming test (FST), sucrose preference test (SPT), and learned helplessness test (LHT) were conducted on days 60, 61, 62, 63, 64, 66–69, and 70–72, respectively