Fig. 3

ITGB4^−/− mice show hyperlocomotion and enhanced sensitivity to D-AMPH in the open field. a Representative tracking paths for ITGB4^−/− and control mice during the 30-min open-field test (n = 9). b ITGB4^−/− mice showed overall hyperactivity during 30 min (5 min per point) test in the open-field (n = 9). c ITGB4^−/− mice traveled further in the 30-min open-field (n = 9). d Bar graph presented the total distance traveled during the 30-min monitoring period after D-AMPH injection (n = 9) .*p < 0.05, ***p < 0.001 vs saline in control group; ###p < 0.001 vs D-AMPH in control group. All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001