Fig. 9

Pathological changes in the hippocampal and prefrontal cortex were found in ITGB4^−/− mice. a, b H&E staining of mouse hippocampus (a) and prefrontal cortex (b) from the control group and the ITGB4^−/− group. All images were obtained at × 200 (upper) and × 400 (lower) magnification. c, d Apoptosis assay of mouse hippocampus (c) and prefrontal cortex (d) from the control group and the ITGB4^−/− group. All images were obtained at × 100 (upper) and × 200 (lower) magnification. e, f SYP protein expression in the hippocampus (e) and prefrontal cortex (f) determined and quantified by western blot normalized against the expression of β-actin. All data are presented as mean ± SEM of four mice in each group. *p < 0.05, **p < 0.01