Fig. 3
From: The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease
Amyloid beta crosses the blood-brain barrier by receptor mediated transport. The blood-brain barrier (BBB) is composed of endothelial cells connected by tight junction proteins. Pericytes and astrocyte end-feet around the endothelial cells support BBB integrity. Aβ can enter and exit the brain by receptor-mediated transcytosis. RAGE is the receptor transporting Aβ from the blood into the brain and low-density lipoprotein receptor-related protein 1(LRP-1) is the receptor transporting Aβ from the brain to the blood. An increase in the expression of RAGE and decrease in the expression of LRP-1 supports the increased accumulation of Aβ in AD