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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation

Fig. 5

Change in c-Fos immunoreactivity in the TNC. a Representative images of c-Fos immunoreactivity in the VEH, NTG, and NTG + 5BDBD groups under × 10 objective lens (the upper row) and × 20 objective lens (the lower row). b Quantification of average number of c-Fos particles revealed that NTG significantly increased c-Fos expression in the TNC. Pretreatment with 5-BDBD inhibited NTG-induced c-Fos expression. One-way ANOVA and Tukey’s multiple comparison test. ***p < 0.001 compared to VEH, ###p < 0.001 compared to NTG group. n = 7/group

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