Fig. 5

Silencing CIITA prevents α-syn-induced neurodegeneration. a Representative × 10 images of TH+ neurons (TH, DAB, brown) in the ipsilateral and contralateral SNpc of WT mice 6 months post-transduction with AAV2-SYN + LGFP, AAV2-SYN + LVA, or AAV2-SYN + LVE. Images were taken with an Olympus BX61 upright microscope. b Unbiased stereology counts of TH+ dopaminergic neurons in the SNpc of WT mice 6 months post-transduction with AAV2-SYN + LGFP, AAV2-SYN + LVA, or AAV2-SYN + LVE. Equal numbers of males and females were used. Ipsilateral and contralateral TH neuron counts were normalized to mean of uninjected side for each group. n = 8–10 per group. Comparisons were made within each individual treatment group using paired t tests and Bonferroni’s multiple comparison correction. *p < 0.016