From: The human microglial HMC3 cell line: where do we stand? A systematic literature review
Markers | Original characterization | CHME3 cells | HMC3 cells | References | |||
---|---|---|---|---|---|---|---|
Resting | Stimulated | Resting | Stimulated | Resting | Stimulated | ||
Myeloid Markers | |||||||
CD68 Ki-M7 | +++ | [17] | |||||
CD68 Ki-M6 | – | [17] | |||||
CD68 EBM/11 | ++ | + | |||||
CD68 | +++ | −/++ | IFNγ: ↑ | ||||
CD11b | +++ | + (and also at mRNA level) | Aβ1–42: ↑ | – | IFNγ: ↑ | ||
CD45 | + | [29] | |||||
IBA1 | + | ||||||
MHCII | – | IFNγ: ↑ | + | −/+ | IFNγ: ↑ | ||
CD14 | – | + | |||||
MCSF-R | + (western immunoblot) | [41] | |||||
TLR1 | + | [40] | |||||
TLR 2 and 6 | +++/++ | HCV NS3 protein: ↑ | [40] | ||||
Polarization markers | |||||||
CD40 | +/++ | Aβ1–42: ↓/↑ | |||||
CD80 | + | [37] | |||||
CD86 | + | Aβ1–42: no effect | |||||
CD163 | + | Aβ1–42: no effect | |||||
CD206 | + | Aβ1–42: no effect | |||||
Chemokine receptors | |||||||
CCR1 | + | [29] | |||||
CCR2 | – | + | |||||
CCR3 | ++ (MFI) | TNFα: ↑ IFNγ: ↑ | [38] | ||||
CCR4 | ++ | [29] | |||||
CCR5 | + | +++ | |||||
CCR10 | + (mRNA level) | TNFα:↑ (mRNA level) | [38] | ||||
CXCR1 | ++ (MFI) | ++ | |||||
CXCR3 | +++ (MFI) | TNFα: slight ↑ IFNγ: slight↑ | +++ | ||||
CX3CR1 | +++ | [29] | |||||
Other markers | |||||||
CD4 | – | [17] | |||||
NSE | +++ | [17] | |||||
GFAP | – | - (including at mRNA level) | – | ||||
NF70KD | – | [17] | |||||
Α7nAcR | + | [44] |