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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease

Fig. 5

Microglial and astrocytic response within the substantia nigra (SN) (a) and striatum (STR) (b) in wild-type (WT) and NOD2-deficient (NOD2−/−) mice after striatal injection of 6-OHDA. The brains were isolated on 14 days after 6-OHDA injection and immunostained for Iba1 (green) and GFAP (green). Immunofluorescent staining indicated that 6-OHDA or MDP promoted microglia activation and astrocytic reaction, whereas NOD2 deficiency reduced the microglial and astrocytic response induced by 6-OHDA or MDP. The cell nuclei were counterstained with DAPI. Scale bars, 50 μm

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Journal of Neuroinflammation

ISSN: 1742-2094