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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease

Fig. 9

Wild-type (WT) mice were placed in a stereotaxic device under 1.5% pentobarbital sodium anesthesia and given 6-OHDA, muramyl dipeptide (MDP, an extrinsic ligand of NOD2), or saline alone into two different sites of the striatum separately. Apocynin was injected i.p. at a dose of 15 mg/kg for 14 days after 6-OHDA or MDP injections. a Apocynin improved the reduction of TH protein expression in the SN on 14 days after 6-OHDA or MDP injection. b The brain sections from the SN showing tyrosine hydroxylase (TH) immunoreactivity on 14 days after striatal infusion of 6-OHDA or MDP. Results are representative of six mice. *p < 0.05, compared with indicated group

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