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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis

Fig. 1

qPCR analyses of ARNT2 expression over the course of MOG-induced chronic EAE. a A cohort of 95 mice were induced for EAE or received only CFA and pertussis as sham-immunized healthy controls; healthy non-immunized mice also served as controls. Mice were scored as outlined in the Materials & Methods and points represent the mean score ± SEM of all mice with clinical symptoms. Tissues from 5 to 8 mice with similar disease scores were harvested at times indicated by arrows (days 7, 10, 14, 18, 25, 32, and 45) representing preclinical, onset, peak, recovery and times with some degree of worsening over time and analyzed by qPCR to obtain ARNT2 message levels normalized to β-actin (b) or analyzed by western blotting to quantify ARNT2 protein compared to tubulin (c). Each point represents the value obtained from one mouse; bars represent the mean ± SD. One way ANOVA followed by Dunnett’s multiple comparison test against CFA/sham immunized mice, ***p < 0.001, ****p < 0.0001

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