Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Complement activation contributes to perioperative neurocognitive disorders in mice

Fig. 5

C3aR blockade attenuates BCSFB disruption in the choroid plexus after surgery. a Representative images of C3 labeling in the choroid plexus of naïve, surgery, and sham mice at 1 day after surgery or sham. b Quantification of C3 fluorescence intensity. c Representative images of IgG staining in the choroid plexus of 3 groups: sham + vehicle, surgery + vehicle, and surgery + C3aRa. d Quantification of IgG fluorescence intensity. e Representative images of ICAM-1 (green) and VCAM-1 (red) labelings in the choroid plexus. Quantification of ICAM-1 (f) and VCAM-1 (g) fluorescence intensity. Nuclear counterstaining with DAPI (blue) (a, c, and e). Scale bar = 100 μm (a, c, and e). Data analyses were performed using one-way analysis of variance followed by Tukey post hoc test (b, d, f, and g); **p < 0.01, ***p < 0.001

Back to article page