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Table 1 Clinical scoring list for bacterial meningitis mouse model

From: Characterization of a Listeria monocytogenes meningitis mouse model

Parameter

Value

Weighted score

Max. score

Weight loss

Normal 5%

0

 

5–10%

1

 

10–15%

2

 

15–20%

3

 

20–25%

4

4

Activity

Normal

0

 

Increased/aggressive

1

 

Mildly diminished

1

 

Diminished

2

 

Severely diminished

3

3

Condition

Normal, does not lay on back

0

 

Upright within 5 s

2

 

Upright within 30 s

4

 

Does not turn upright

6

6

Coat

Normal

0

 

Diminished grooming

1

 

Soiled

1

 

Piloerection

1

3

Posture

Normal

0

 

Slightly hunched back

1

2

Severe hunched back

2

 

Eyes

Normal

0

 

Protruding

1

 

Closed eyelids

1

 

Discharge

1

4

Respiration rate (per min)

> 150

0

 

100–150

1

 

75–100

2

 

50–75

3

 

< 50

4

4

Breathing

Irregular

2

 

Labored

2

4

Neurological examination

Normal

0

 

Coordination problem

2

 

Paresis/paralysis

2

 

Epileptic seizure

2

 

Status epilepticus

6

10

Humane endpoints

Total score ≥ 15

  

Status epilepticus

  

≥ 2 seizures in 15 min

  

Hemiparalysis

  

≥ 25% weight loss

  
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Journal of Neuroinflammation

ISSN: 1742-2094