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Table 1 Clinical scoring list for bacterial meningitis mouse model

From: Characterization of a Listeria monocytogenes meningitis mouse model

Parameter Value Weighted score Max. score
Weight loss Normal 5% 0  
5–10% 1  
10–15% 2  
15–20% 3  
20–25% 4 4
Activity Normal 0  
Increased/aggressive 1  
Mildly diminished 1  
Diminished 2  
Severely diminished 3 3
Condition Normal, does not lay on back 0  
Upright within 5 s 2  
Upright within 30 s 4  
Does not turn upright 6 6
Coat Normal 0  
Diminished grooming 1  
Soiled 1  
Piloerection 1 3
Posture Normal 0  
Slightly hunched back 1 2
Severe hunched back 2  
Eyes Normal 0  
Protruding 1  
Closed eyelids 1  
Discharge 1 4
Respiration rate (per min) > 150 0  
100–150 1  
75–100 2  
50–75 3  
< 50 4 4
Breathing Irregular 2  
Labored 2 4
Neurological examination Normal 0  
Coordination problem 2  
Paresis/paralysis 2  
Epileptic seizure 2  
Status epilepticus 6 10
Humane endpoints Total score ≥ 15   
Status epilepticus   
≥ 2 seizures in 15 min   
Hemiparalysis   
≥ 25% weight loss