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Table 2 Comparison of baseline brain MRI features between Japanese and Caucasian patients with MS

From: A comparison of brain magnetic resonance imaging lesions in multiple sclerosis by race with reference to disability progression

  Mean Median (IQR) Mean Median (IQR) p
  Japanese patients (n = 93) Caucasian patients (n = 72)  
Number of T2W-lesions 62 50 (27–96) 73 65 (24–108) 0.08
T2W-lesion volumes (cm3) 11.5 7.8 (2.3–16.9) 8.0 5.3 (2.4–12.2) 0.12
Each T2W-lesion volume (mm3) 174 140 (78–224) 118 85 (63–138) < 0.0001
  Japanese patients (n = 83) Caucasian patients (n = 233)  
NBV (cm3) 942.6 954.1 (903.9–980.2) 972.9 977.9 (940.4–1002.6) < 0.0001
  Japanese patients (n = 45) Caucasian patients (n = 148)  
NWMV (cm3) 467.4 466.1 (446.5–486.1) 486.9 487.7 (473.2–501.4) < 0.0001
  Japanese patients (n = 52) Caucasian patients (n = 165)  
NCGMV (cm3) 441.3 438.3 (418.6–473.1) 449.8 452.0 (429.9–471.7) 0.08
  Japanese patients (n = 73) Caucasian patients (n = 207)  
NDGMV (cm3) 37.0 36.7 (33.3–40.6) 40.8 41.4 (38.0–43.8) < 0.0001
Normalized thalamic volume (cm3) 17.2 17.3 (15.7–19.0) 18.8 18.9 (17.6–20.2) < 0.0001
  1. Statistical comparisons were performed using linear regression with adjustments for age, sex, duration of disease from the first symptom, and exposure to previous MS treatment. We calculated the average T2W-lesion volume by dividing overall T2W-lesion volume by the number of T2W-lesions in individual patients
  2. IQR interquartile range, MRI Magnetic resonance imaging, MS multiple sclerosis, NBV normalized brain volume, NCGMV normalized cortical gray matter volume, NDGMV normalized deep gray matter volume, NWMV normalized white matter volume