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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol

Fig. 5

Gro1 suppresses proliferation of neuroblasts and increases proliferation of oligodendrocytes. Immunocytochemistry of mNPC treated with Gro1 (80 ng/mL) for 72 h or left untreated. a Cells were co-stained for Ki67- and Tuj-1, Ng2, or GFAP. The graphs depict the percentage of Ki67+ proliferating cells among Tuj-1+ neuroblasts, Ng2+ oligodendrocyte precursors, or GFAP+ astrocytes. b Cells were co-stained for p16, Tuj-1, Ng2, and GFAP. The graphs depict the percentage of p16+ non-proliferating cells among Tuj-1+ neuroblasts, Ng2+ oligodendrocyte precursors, or GFAP+ astrocytes. Counting was performed in triplicate (> 500 cells per sample). Data were tested across groups using t test or Wilcoxon rank-sum test. Data are presented as a mean ± SEM

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