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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Environmental enrichment reduces adolescent anxiety- and depression-like behaviors of rats subjected to infant nerve injury

Fig. 1

Experimental procedures and timeline. SNI surgery was performed by ligation and transection of the tibia and common peroneal branches, leaving the sural nerve intact. Experiment 1: Behavior tests and ELISA to measure the anxiety- and depression-like behaviors and inflammatory profile. Experiment 2: ICV MIN to evaluate the effect of a microglia inhibitor on the anxiety- and depression-like behaviors and inflammatory profile. Experiment 3: Test the effects of EE on anxiety- and depression-like behaviors and inflammatory profile of rats subjected to infant SNI. SNI spared nerve injury, ELISA enzyme-linked immune-absorbent assay, ICV intracerebroventricular, MIN minocycline, EE environmental enrichment, P postnatal days, POD postoperative days

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Journal of Neuroinflammation

ISSN: 1742-2094