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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Environmental enrichment reduces adolescent anxiety- and depression-like behaviors of rats subjected to infant nerve injury

Fig. 4

ICV MIN decreased infant SNI-induced anxiety- and depression-like behaviors. Infant SNI decreased a center duration and b distance from POD 20 to POD 40 in the open field test, f open arm duration from POD 20 to POD 40, e open arm entrances on POD 40 in the elevated plus maze test, and d sucrose intake percentage on POD 45. ICV MIN increased center duration and distance in the open field test, open duration and open entrance on POD 40 in the elevated plus maze test, and sucrose intake percentage on POD 45. ICV MIN did not affect the total distance traveled in the open field test (no difference between the four groups) and did not affect any behaviors of the sham rats. Infant SNI decreased g paw withdrawal threshold and h increased guarding score (guarding scores in the two sham groups were zero) and i response to acetone from POD 20 to POD 40, while ICV MIN did not affect these values in sham or SNI rats. k SNI decreased center/total distance compared to the sham group, while ICV MIN decreased that effect on POD40. n = 6–8. “a” denotes the statistically significant difference compared to the sham plus vehicle group. “b” denotes the statistically significant difference compared to the SNI plus vehicle group

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