Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes

Fig. 1

α-Synuclein abolishes the anti-inflammatory role of Drd2 in vivo. a–c Quinpirole inhibited the pro-inflammatory mediators production in the SNc of wild-type mice treated with MPTP, but not in A53T transgenic (A53Ttg/tg) mice. The levels of IL-1β (a), TNF-α (b), and IL-6 (c) evaluated by ELISA in the SNc of wild-type mice and A53Ttg/tg mice. d–h Quinpirole inhibited the activation of TLR4-NF-κB signal pathways in the SNc of wild-type mice treated with MPTP, but not in A53Ttg/tg mice. Representative immunoblot (d) and quantitative analysis of TLR4 (e), p-TAK1 (f), p-IKK (g), and p-p65 (h) in the SNc of wild-type mice and A53Ttg/tg mice. Data are presented as the mean ± S.E.M, n = 6, two-way ANOVA, *p < 0.05, **p < 0.01 vs. control group, #p < 0.05 vs. MPTP treatment group

Back to article page