Fig. 2

α-Synuclein abolishes the anti-inflammatory role of Drd2 in astrocytes. a, b Drd2 agonists inhibited LPS-induced the levels of the indicated genes in astrocytes evaluated by qPCR analysis (a) and Elisa analysis (b). c, d Drd2 agonists inhibited MMP⁺-induced the levels of the indicated genes in astrocytes evaluated by qPCR analysis (c) and Elisa analysis (d). e, f Drd2 agonists failed to suppress the levels of the indicated genes in astrocytes treated with wide-type (WT) α-Syn evaluated by qPCR analysis (e) and Elisa analysis (f). g, h Drd2 agonists failed to suppress the levels of the indicated genes in astrocytes treated with A53T mutant α-Syn evaluated by qPCR analysis (g) and Elisa analysis (h). i, j Drd2 agonist failed to suppress the levels of the indicated genes in astrocytes from A53T transgenic (A53T^tg/tg) mice evaluated by qPCR analysis (i) and Elisa analysis (j). Data are presented as the mean ± S.E.M from four independent experiments, one-way ANOVA, ^*p < 0.05, ^**p < 0.01 vs. control group, ^#p < 0.05 vs. LPS/MPP⁺ treatment group