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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes

Fig. 3

α-Synuclein cancels the neuroprotective effect of Drd2 in vitro. a–c Quinpirole protects DA neurons against LPS-induced toxicity. Mesencephalic primary neurons were incubated with the conditioned medium (CM) from astrocyte treated with LPS and quinpirole. The representative pictures of TH+ neuron immunostaining (a), quantification of TH+ cell number (b), and mean total neuritis length (c). d–f Quinpirole failed to protect DA neurons against wide-type (WT) α-Syn or A53T mutant α-Syn-induced toxicity. Mesencephalic primary neurons were incubated with the CM from astrocyte treated with WT α-Syn or A53T α-Syn and quinpirole. The representative pictures of TH+ neuron immunostaining (d), quantification of TH+ cell number (e), and mean total neuritis length (f). Data are presented as the mean ± S.E.M from four independent experiments, one-way ANOVA, *p < 0.05 vs. control group, and #p < 0.05 vs. LPS treatment group

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