Fig. 2

Effect of PEA-OXA on mast cells density and pain behavior. The blue toluidine staining for highlight the mast cells, a for sham group. b 14 days after sciatic nerve crush, there is a significant increase in mast cell number in sciatic nerve from vehicle group. c How daily treatment with PEA-OXA significantly reduces the presence of mast cell compared to vehicle group as shown by d. e, f The analgesic effect of daily treatment of PEA-OXA 10 mg\kg, on thermal hyperalgesia (Plantar test) and mechanical allodynia. g, g1 The c-fos expressions by western blot analysis in the lumbar portion of the spinal cord. h, h1 Western blot analysis on the lumbar portion of the spinal cord for NAAA expressions. Each data are expressed as mean ± SEM from N  =  10 mice for each group. ***p < 0.001 vs corresponding sham group. #p < 0.05 vs. vehicle group, ##p < 0.01 vs vehicle group, ###p < 0.001 vs. vehicle group