Skip to main content
Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets

Fig. 3

Correlation between behavioral deficits and dopaminergic (TH+) neuronal loss in the SNpc induced by successive PGJ2 microinfusions. a All groups of rats treated with PGJ2 (shades of red circles) exhibited behavioral deficits. When compared to DMSO-treated rats (white, gray and black circles), those treated with 2X and 4X PGJ2 significantly increased usage of the ipsilateral forelimb as assessed by the cylinder test (see Materials and Methods). Statistical significance was estimated with the Student’s T test to compare DMSO and PGJ2-treated groups, and between two PGJ2-treated groups. The p values in red indicate the values that are significantly (< 0.05) different from DMSO-injected rats. N = 4 to 8 rats per group. b In the PGJ2-treated but not in the control (DMSO) rats, dopaminergic neuronal loss (TH+) in the ipsilateral SNpc (x-axis) inversely correlates with forelimb usage asymmetry (y-axis). X = number of injections (once per week)

Back to article page