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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets

Fig. 6

Successive PGJ2 microinfusions induce aggregate-like ubiquitinated protein (a) and pS129 α-synuclein (b) deposits in dopaminergic neurons. Immunostaining for ubiquitinated proteins (red in a), pS129 α-synuclein (red in b), and TH+ neurons (blue in a and b) at 4 weeks after two (2X) and four (4X) PGJ2 microinjections. Dopaminergic neurons in the SNpc of PGJ2-treated rats exhibit aggregate-like ubiquitin conjugates and pS129 α-synuclein neuronal inclusions (white arrows). Scale bar = 50 μm. c Values on the y-axis represent the optical density (OD) ratios between ipsilateral SNpc over the contralateral, normalized to the TH+ signal. Black circles, control, DMSO-treated rats; red circles, PGJ2-treated rats. Statistical significance was estimated with the Student’s T test to compare DMSO and PGJ2-treated groups. The p value in red indicates significant (p < 0.05) difference from DMSO-injected rats. N = 3 rats per group. X = number of injections (once per week)

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