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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice

Fig. 3

Ibrutinib significantly reduced the LPS-induced increases in the mRNA levels of the proinflammatory cytokines COX-2 and IL-6 in primary microglial cells. a Primary microglial cells were treated with vehicle (1% DMSO) or ibrutinib (1 μM) for 30 min, followed by PBS or LPS (1 μg/ml) for 5.5 h, and RT-PCR was conducted. b–f Quantification of the data shown in a (COX-2, IL-1β, IL-6, iNOS, and TNF-α: con, n = 4; LPS, n = 4; ibrutinib+LPS, n = 4). *p < 0.05, ***p < 0.001

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