Fig. 7

Ibrutinib significantly reduced LPS-induced BV2 microglial cell migration. a Monolayers of BV2 microglial cells were scratched with a fine tip, pretreated with vehicle (1% DMSO) or ibrutinib (500 nM) for 1 h, and then treated with PBS or LPS (100 ng/ml) for 23 h. Images of the wound gap were acquired at 0 h (i.e., immediately after scratching) and 24 h. b Quantification of the data shown in a (con, n = 22; LPS, n = 22; ibrutinib+LPS, n = 22). ***p < 0.001