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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy

Fig. 2

Increased tau pathology, IL-1α/IL-1β, and microglial activation in 6-month-old hTau/Cx3cl1−/− and hTau/Cx3cl1105Δ mice. a, b Western blotting revealed increases in AT8+ tau in the hippocampus of hTau/Cx3cl1−/− and hTau/Cx3cl1105Δ mice compared to hTau controls. c AT8 IHC revealed increased reactivity in the CA3 regions of hTau/Cx3cl1−/− and hTau/Cx3cl1105Δ groups compared to hTau controls. Scale bar, 30 μm. d Significant increases in both CD45 and F4/80 immunoreactivities were detected and quantified (e) in the cortex of hTau/Cx3cl1−/− and hTau/Cx3cl1105Δ mice compared to controls. f A significant increase in IL-1α and IL-1β was observed in both hTau/Cx3cl1−/− and hTau/Cx3cl1105Δ mice via ELISA. n = 6 mice per group except for ELISA (n = 10). Three independent experiments were performed for each analysis. Error bars represent SEM. One-way ANOVA followed by Tukey’s post hoc test: *p < 0.05, **p < 0.01, ***p < 0.001

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