Fig. 4

Impaired learning in hTau/Cx₃cl1^−/− and hTau/Cx₃cl1^105Δ mice. Morris water maze was performed on 12-month-old mice. Mice were subjected to a 3-day visible training paradigm (a), followed by a 5-day hidden trial period (memory testing). b Where latency to reach the platform was recorded (seconds, sec). c Analysis of the linear regression slope adjusted for each genotype revealed that hTau mice learned the task better than hTau/Cx₃cl1^−/− or hTau/Cx₃cl1^105Δ mice over the 5-day hidden trial period. d hTau mice had a much lower savings index than hTau/Cx₃cl1^−/− or hTau/Cx₃cl1^105Δ mice during the 5-day hidden trial period. e hTau mice show higher acquisition index than hTau/Cx₃cl1^−/− or hTau/Cx₃cl1^105Δ mice during the 5-day testing period. Mean + SEM; one-way ANOVA followed by Tukey’s post hoc test: *p < 0.05, **p < 0.01, ***p < 0.001; n = 10 mice per group