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Table 2 Neurological Severity Score

From: Impact of nutrition on inflammation, tauopathy, and behavioral outcomes from chronic traumatic encephalopathy

Task Description Score (success/failure)
Exit circle Ability and initiative to exit a circle of 30 cm in diameter within 3 min  
Monoparesis/hemiparesis Assess paresis of upper and/or lower limb 0/1
Straight walk/gait Initiative and motor ability to walk straight  
Startle reflex Innate reflex assessment; mouse should bounce in response to a loud hand clap 0/1
Seeking behavior Physiological behavior as a sign of “interest” in the environment  
Beam balancing Ability to balance on a beam of 7 mm in width for at least 10 s 0/1
Round stick balancing Ability to balance on a round stick of 5 mm in diameter for at least 10 s  
Beam walk: 3 cm Ability to cross a 30-cm-long beam: 3-cm-wide beam 0/1
Beam walk: 2 cm Ability to cross a 30-cm-long beam (increased difficulty): 2-cm-wide beam  
Beam walk: 1 cm Ability to cross a 30-cm-long beam (increased difficulty): 1-cm-wide beam 0/1
Total score   Of 10
  1. Adapted from [29]. One point is awarded for the lack of a tested reflex or for the inability to perform the tasks outlined in the table, and no point for succeeding. A maximal Neurological Severity Score (NSS) of 10 points thus indicates severe neurological dysfunction, with failure of all tasks, and a normal healthy mouse would get a score of a zero on the tasks above. Roughly, NSS score: 1–4, mild TBI; 5–7, moderate TBI; 8–10, severe TBI