Fig. 4
From: Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease
Proposed model of immunosenescence over time. We suggest that immunosenescence is related to the cumulative effects of many inflammatory events throughout life, including infection, metabolic disorders, or genetic risks. It may be possible to reduce immunosenescence by modifying lifestyle, leading to a reduced cumulative effect, which may subsequently decrease the risk of developing AD