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Table 2 The upregulated and downregulated genes in rat neuropathic pain model

From: Analyses of gene expression profiles in the rat dorsal horn of the spinal cord using RNA sequencing in chronic constriction injury rats

Gene name Locus Fold change p value Biological process
Cxcl13 chr14:15253125-15258207 6.426350091 0.001461007 Chemokine-mediated signaling pathway
Reg3b chr4:109467272-109470510 4.596165659 0.00238738 Negative regulation of cell death
Plac8 chr14:10692764-10714524 2.75098502 0.02157393 Negative regulation of apoptotic process
C1qc chr5:155255005-155258392 2.72105301 0.003170161 Innate immune response
Ccl2 chr10:69412017-69413870 2.696533508 0.000586007 Glial cell migration
C1qa chr5:155261250-155264143 2.585336373 0.001012602 Innate immune response
C3 chr9:9721105-9747167 2.470300657 0.007779142 Complement activation
C1qb chr5:155246447-155252003 2.318601492 0.004223697 Innate immune response
C4a chr20:4302347-4508214 2.268474076 0.003906162 Complement activation
C4a chr20:2651599-2678141 2.117474349 0.002292613 Complement activation
Fcer1g chr13:89601896-89606326 1.897610848 0.009152089 Innate immune response
Ngfr chr10:83389847-83408061 1.889723015 0.012534711 Sensory perception of pain
Fcgr3a chr13:89385859-89396051 1.846156689 0.020151454 Regulation of sensory perception of pain
Fyb chr2:55835151-55983804 1.841013316 0.003152222 Immune response
Fcgr1a chr2:198430530-198458041 1.820562407 0.032185553 Regulation of immune response
LOC103691423 chr2:23260651-23260965 1.812907143 0.032394733  
Cd22 chr1:89314558-89329418 1.806446581 0.027087834 Cell adhesion
Gapt chr2:41869556-41871858 1.801373741 0.01683096 Innate immune response
Ly86 chr17:28104589-28191436 1.801122811 0.029526635 Innate immune response
Cd33 chr1:98398660-98402968 1.787375322 0.005028128 Regulation of immune response
Pld4 chr6:137323713-137331231 1.78323674 0.008341961 Phagocytosis
Ltc4s chr10:35737664-35739625 1.774305996 0.014581973 Response to axon injury
Cd53 chr2:209489279-209537087 1.752658145 0.009085537 Cell surface receptor signaling pathway
Ctsz chr3:172527107-172537877 1.750656844 0.009448762 Regulation of neuron death
Clec4a1 chr4:155947453-155959993 1.73513319 0.007661068 Adaptive immune response
Rpe65 chr2:266141581-266169197 1.717980882 0.005397693 Cellular response to electrical stimulus
Irf8 chr19:54314865-54336640 1.713827049 0.025622097 Phagocytosis
Atf3 chr13:109817728-109849632 1.667935639 0.005824841 Positive regulation of cell proliferation
Apobec1 chr4:155386711-155401480 1.665506432 0.016894935 Regulation of cell proliferation
Tmem176a chr4:78458625-78462423 1.661562833 0.01247483 Cell differentiation
Cyp4b1 chr5:134508730-134526089 1.656053246 0.040180738 Cell differentiation
Gpr31 chr1:53519829-53520788 1.649462641 0.019751159 signal transduction
Aoah chr17:45872414-46115004 1.639719248 0.031572447 Inflammatory response
LOC102557117 chr5:187312-187688 1.636194027 0.027745501  
Clec7a chr4:163216163-163227334 1.629244213 0.022249116 Innate immune response
Bin2 chr7:142273833-142300382 1.625336862 0.00919119 Cell chemotaxis
Gpr34 chrX:10023489-10031167 1.618400204 0.007940879 Signal transduction
Mx1 chr11:37891156-37914983 1.613580093 0.003770887 Innate immune response
Gpr183 chr15:108364701-108376221 1.613459608 0.003571085 Adaptive immune response
AABR07001573.2 chr1:53220397-53284319 1.605472328 0.042391557  
Cd68 chr10:56268720-56270640 1.59862216 0.025231623 Neutrophil degranulation
AC115371.1 chr15:33606124-33611579 1.597574602 0.016091626  
Oosp1 chr1:228032983-228053645 1.593938444 0.009835678 Response to stimulus
Tmem176b chr4:78450724-78458179 1.581317379 0.012542608 Cell differentiation
Adgre1 chr9:9431860-9585865 1.578724864 0.04691516 Adaptive immune response
Fcgr2b chr13:89327794-89433815 1.569218908 0.024948119 Immune response
Cyth4 chr7:119820537-119845003 1.56917098 0.047508716 Regulation of molecular function
Aif1 chr20:5161333-5166448 1.565044457 0.027459054 Response to axon injury
Plek chr14:100151210-100217913 1.548834783 0.020475153 Integrin-mediated signaling pathway
Wipf3 chr4:84597323-84676775 1.545203106 0.024900292 Cell differentiation
Itgad chr1:199495298-199623960 1.537780288 0.044440601 Microglial cell activation
RGD1309350 chr1:213577122-213580542 1.527740296 0.000267242 Purine nucleobase metabolic process
Anxa3 chr14:14364008-14426437 1.51105029 0.043685994 Phagocytosis
Laptm5 chr5:149047681-149069719 1.508262862 0.03919455 Transport
Tmem154 chr2:183674522-183711812 1.504875551 0.034809815  
Csf1r chr18:56414488-56458300 1.503532191 0.008357977 Cytokine-mediated signaling pathway
Urgcp chr14:85957716-85991211 0.32013414 0.002977579 Cell cycle
LOC500300 chr4:148782479-148784562 0.58414901 0.0290017 Regulation of autophagy
Klhdc7a chr5:158436757-158439078 0.594907041 0.026052604 Protein ubiquitination
AABR07026893.1 chr17:3729421-3729810 0.620034111 0.041049018  
Dusp1 chr10:16970626-16973418 0.627386061 0.031077843 Inactivation of MAPK activity
Plac9 chr16:3851270-3866008 0.633314755 0.03114494  
AABR07042903.1 chr19:14345993-14346891 0.666129407 0.046588447