Table 2 The upregulated and downregulated genes in rat neuropathic pain model
Gene name | Locus | Fold change | p value | Biological process |
|---|---|---|---|---|
Cxcl13 | chr14:15253125-15258207 | 6.426350091 | 0.001461007 | Chemokine-mediated signaling pathway |
Reg3b | chr4:109467272-109470510 | 4.596165659 | 0.00238738 | Negative regulation of cell death |
Plac8 | chr14:10692764-10714524 | 2.75098502 | 0.02157393 | Negative regulation of apoptotic process |
C1qc | chr5:155255005-155258392 | 2.72105301 | 0.003170161 | Innate immune response |
Ccl2 | chr10:69412017-69413870 | 2.696533508 | 0.000586007 | Glial cell migration |
C1qa | chr5:155261250-155264143 | 2.585336373 | 0.001012602 | Innate immune response |
C3 | chr9:9721105-9747167 | 2.470300657 | 0.007779142 | Complement activation |
C1qb | chr5:155246447-155252003 | 2.318601492 | 0.004223697 | Innate immune response |
C4a | chr20:4302347-4508214 | 2.268474076 | 0.003906162 | Complement activation |
C4a | chr20:2651599-2678141 | 2.117474349 | 0.002292613 | Complement activation |
Fcer1g | chr13:89601896-89606326 | 1.897610848 | 0.009152089 | Innate immune response |
Ngfr | chr10:83389847-83408061 | 1.889723015 | 0.012534711 | Sensory perception of pain |
Fcgr3a | chr13:89385859-89396051 | 1.846156689 | 0.020151454 | Regulation of sensory perception of pain |
Fyb | chr2:55835151-55983804 | 1.841013316 | 0.003152222 | Immune response |
Fcgr1a | chr2:198430530-198458041 | 1.820562407 | 0.032185553 | Regulation of immune response |
LOC103691423 | chr2:23260651-23260965 | 1.812907143 | 0.032394733 | Â |
Cd22 | chr1:89314558-89329418 | 1.806446581 | 0.027087834 | Cell adhesion |
Gapt | chr2:41869556-41871858 | 1.801373741 | 0.01683096 | Innate immune response |
Ly86 | chr17:28104589-28191436 | 1.801122811 | 0.029526635 | Innate immune response |
Cd33 | chr1:98398660-98402968 | 1.787375322 | 0.005028128 | Regulation of immune response |
Pld4 | chr6:137323713-137331231 | 1.78323674 | 0.008341961 | Phagocytosis |
Ltc4s | chr10:35737664-35739625 | 1.774305996 | 0.014581973 | Response to axon injury |
Cd53 | chr2:209489279-209537087 | 1.752658145 | 0.009085537 | Cell surface receptor signaling pathway |
Ctsz | chr3:172527107-172537877 | 1.750656844 | 0.009448762 | Regulation of neuron death |
Clec4a1 | chr4:155947453-155959993 | 1.73513319 | 0.007661068 | Adaptive immune response |
Rpe65 | chr2:266141581-266169197 | 1.717980882 | 0.005397693 | Cellular response to electrical stimulus |
Irf8 | chr19:54314865-54336640 | 1.713827049 | 0.025622097 | Phagocytosis |
Atf3 | chr13:109817728-109849632 | 1.667935639 | 0.005824841 | Positive regulation of cell proliferation |
Apobec1 | chr4:155386711-155401480 | 1.665506432 | 0.016894935 | Regulation of cell proliferation |
Tmem176a | chr4:78458625-78462423 | 1.661562833 | 0.01247483 | Cell differentiation |
Cyp4b1 | chr5:134508730-134526089 | 1.656053246 | 0.040180738 | Cell differentiation |
Gpr31 | chr1:53519829-53520788 | 1.649462641 | 0.019751159 | signal transduction |
Aoah | chr17:45872414-46115004 | 1.639719248 | 0.031572447 | Inflammatory response |
LOC102557117 | chr5:187312-187688 | 1.636194027 | 0.027745501 | Â |
Clec7a | chr4:163216163-163227334 | 1.629244213 | 0.022249116 | Innate immune response |
Bin2 | chr7:142273833-142300382 | 1.625336862 | 0.00919119 | Cell chemotaxis |
Gpr34 | chrX:10023489-10031167 | 1.618400204 | 0.007940879 | Signal transduction |
Mx1 | chr11:37891156-37914983 | 1.613580093 | 0.003770887 | Innate immune response |
Gpr183 | chr15:108364701-108376221 | 1.613459608 | 0.003571085 | Adaptive immune response |
AABR07001573.2 | chr1:53220397-53284319 | 1.605472328 | 0.042391557 | Â |
Cd68 | chr10:56268720-56270640 | 1.59862216 | 0.025231623 | Neutrophil degranulation |
AC115371.1 | chr15:33606124-33611579 | 1.597574602 | 0.016091626 | Â |
Oosp1 | chr1:228032983-228053645 | 1.593938444 | 0.009835678 | Response to stimulus |
Tmem176b | chr4:78450724-78458179 | 1.581317379 | 0.012542608 | Cell differentiation |
Adgre1 | chr9:9431860-9585865 | 1.578724864 | 0.04691516 | Adaptive immune response |
Fcgr2b | chr13:89327794-89433815 | 1.569218908 | 0.024948119 | Immune response |
Cyth4 | chr7:119820537-119845003 | 1.56917098 | 0.047508716 | Regulation of molecular function |
Aif1 | chr20:5161333-5166448 | 1.565044457 | 0.027459054 | Response to axon injury |
Plek | chr14:100151210-100217913 | 1.548834783 | 0.020475153 | Integrin-mediated signaling pathway |
Wipf3 | chr4:84597323-84676775 | 1.545203106 | 0.024900292 | Cell differentiation |
Itgad | chr1:199495298-199623960 | 1.537780288 | 0.044440601 | Microglial cell activation |
RGD1309350 | chr1:213577122-213580542 | 1.527740296 | 0.000267242 | Purine nucleobase metabolic process |
Anxa3 | chr14:14364008-14426437 | 1.51105029 | 0.043685994 | Phagocytosis |
Laptm5 | chr5:149047681-149069719 | 1.508262862 | 0.03919455 | Transport |
Tmem154 | chr2:183674522-183711812 | 1.504875551 | 0.034809815 | Â |
Csf1r | chr18:56414488-56458300 | 1.503532191 | 0.008357977 | Cytokine-mediated signaling pathway |
Urgcp | chr14:85957716-85991211 | 0.32013414 | 0.002977579 | Cell cycle |
LOC500300 | chr4:148782479-148784562 | 0.58414901 | 0.0290017 | Regulation of autophagy |
Klhdc7a | chr5:158436757-158439078 | 0.594907041 | 0.026052604 | Protein ubiquitination |
AABR07026893.1 | chr17:3729421-3729810 | 0.620034111 | 0.041049018 | Â |
Dusp1 | chr10:16970626-16973418 | 0.627386061 | 0.031077843 | Inactivation of MAPK activity |
Plac9 | chr16:3851270-3866008 | 0.633314755 | 0.03114494 | Â |
AABR07042903.1 | chr19:14345993-14346891 | 0.666129407 | 0.046588447 | Â |