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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD

Fig. 1

Concentrations of CA140 up to 25 μM were not toxic in BV2 microglial cells. a Structure of CA140. b Stability studies of CA140 and dopamine (DA) in vitro. c BV2 microglial cells were treated with vehicle (1% DMSO) or CA140 at various concentrations (1, 5, 10, 25, or 50 μM) for 24 h, and cell viability was measured (n = 8 for each dose). d BV2 microglial cells were pretreated with LPS (1 μg/mL) or PBS for 30 min, followed by treatment with vehicle (1% DMSO) or CA140 (10 μM) for 6 h and immunostaining with anti-CD11b and anti-F-actin antibodies. ***p < 0.001

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