Fig. 10

CA140 significantly reduced microglial and astrocyte activation in 5xFAD mice. a, d Representative images of the hippocampus (a) and cortex (d) from 5xFAD mice injected with vehicle (10% DMSO, i.p.) or CA140 (30 mg/kg, i.p.) daily for 2 weeks; immunohistochemistry was performed with anti-Iba-1 antibody. b, c Quantification of data from a (hippocampus CA1 and DG: con, n = 8 mice; CA140, n = 8 mice). e Quantification of data from d (cortex: con, n = 8 mice; CA140, n = 8 mice). f, i Representative images of the hippocampus (f) and cortex (i) from 5xFAD mice injected with vehicle (10% DMSO, i.p.) or CA140 (30 mg/kg, i.p.) daily for 2 weeks; immunohistochemistry was performed with anti-GFAP antibody. g, h Quantification of data from f (hippocampus CA1 and DG: con, n = 6 mice; CA140, n = 6 mice). j Quantification of data from i (cortex: con, n = 6 mice; CA140, n = 6 mice). ***p < 0.0001