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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD

Fig. 8

Pretreatment with LPS followed by CA140 treatment significantly decreased microglial and astrocyte activation in wild-type mice. a Wild-type mice were injected with LPS (10 mg/kg, i.p.), followed 30 min later by injection twice with CA140 (30 mg/kg, i.p.) at an interval of 1 h and a third injection (30 mg/kg, i.p.) at an interval of 30 min. The mice were perfused, fixed, and immunostained with anti-Iba-1 antibody. b, c Quantification of data from a (con, n = 5 mice; LPS, n = 5 mice; LPS + CA140, n = 5 mice). d Wild-type mice were injected with LPS (10 mg/kg, i.p.), followed 30 min later by injection twice with CA140 (30 mg/kg, i.p.) at an interval of 1 h and a third injection (30 mg/kg, i.p.) at an interval of 30 min. The mice were perfused, fixed, and immunostained with anti-GFAP antibody. e, f Quantification of data from d (con, n = 5 mice; LPS, n = 5 mice; LPS + CA140, n = 5 mice). ***p < 0.0001

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