Fig. 5

Newborn dentate granule neurons in Tg26 mice harbor decreased apical dendritic spine density. a Diagram of dendritic spine types and representative images of retroviral eGFP-labeled apical dendritic arbors from WT and Tg26 granule neurons. b–e Quantitative analysis of total dendritic density as well as densities for specific spine types. Data is presented as the mean ± SEM from four mice (three males and one female per genotype), with at least 200 μm of apical dendritic arbors from six to eight granule neurons being analyzed per mouse. Scale bar in a, 6.25 μm. *p < 0.05, **p < 0.01, and ***p < 0.001 indicate statistical changes compared with the corresponding WT dendritic arbor