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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

Fig. 5

CAY10444 (CAY) administration attenuates expression level of surface markers of M1 polarization in post-ischemic brain. Mice were challenged with tMCAO, and CAY (0.5 mg/kg) was administered intraperitoneally immediately after reperfusion. The effect of CAY on mRNA expression of M1 surface markers in 1 day (a–d) and 3 days (e–h) post-ischemic brain was determined by qRT-PCR analysis. n = 5 mice per group. *p < 0.05 and **p < 0.01 versus sham group. #p < 0.05 versus vehicle-administered tMCAO group (tMCAO+veh)

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Journal of Neuroinflammation

ISSN: 1742-2094