Fig. 6From: Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarizationCAY10444 (CAY) administration attenuates expression level of soluble markers of M1 polarization in post-ischemic brain. Mice were challenged with tMCAO, and CAY (0.5 mg/kg) was administered intraperitoneally immediately after reperfusion. The effect of CAY on mRNA expression of M1 soluble markers in 1 day (a–d) and 3 days (e–h) post-ischemic brain was determined by qRT-PCR analysis. n = 5 mice per group. *p < 0.05, **p < 0.01, and ***p < 0.001 versus sham group. #p < 0.05, ##p < 0.01, and ###p < 0.001versus vehicle-administered tMCAO group (tMCAO+veh)Back to article page