Fig. 7

CAY10444 (CAY) administration attenuates tMCAO-induced microglial NF-κB expression in post-ischemic brain. Mice were challenged with tMCAO, and CAY (0.5 mg/kg) was administered intraperitoneally immediately after reperfusion. The effect of CAY on NF-κB expression in activated microglia was determined by NF-κB(p65)/Iba1 double immunohistochemical analysis in 1 day post-ischemic brain. a Representative images of NF-κB(p65)/Iba1-immunopositive cells in ischemic core regions. Scale bars, 50 μm. b Quantification of the number of NF-κB(p65)- and NF-κB(p65)/Iba1-immunopositive cells. n = 4~ 5 mice per group. ***p < 0.001 versus sham group and ^###p < 0.001 versus vehicle-administered tMCAO group (tMCAO+veh)