Skip to main content

Table 2 Evidence for beneficial effects of administered DHEA/DHEAS or metabolites reported in pre-clinical studies

From: Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?

Demonstrated beneficial effects

Reference

General neuroprotective effects demonstrated both in vitro and in vivo in:

 E18 Sprague–Dawley rat hippocampal cell culture model of N-methyl-D-aspartate (NMDA) neurotoxicity

[187]

 HT-22 mouse hippocampal cell line model of glutamate and amyloid-β neurotoxicity

[188]

 E18 Sprague–Dawley rat cerebral cortical cell culture anoxia model

[189]

 Mouse hippocampal neurodegeneration model

[190]

 Rats with induced forebrain ischemia model

[191]

 Rat hippocampal slice culture ischemia model

[192]

 Primary rat cerebellar granule cell anoxic and glucose deprivation model

[193]

 Mouse spinal cord ischemic injury model

[194]

 Rat inflammatory neurodegeneration model

[195]

 P19 neuronal NMDA-induced excitotoxicity cell line model

[87]

 Aged rat brain model

[196]

 Rat Corpus striatum (CS) and the nucleus accumbens (NAc) model of assessing effects of DHEA on monoamine oxidase (MOA) activity

[197]

 Human SH-SY5Y neuroblastoma cell line model assessing the effects of neurosteroids on mitochondrial bioenergetics

[198]

 Rat brain 3-nitropropionic acid (3-NP) induced neurotoxicity model

[199]

 Transient brain ischemic mouse model

[200]

 Primary male and female mouse cultured hippocampal neurons, as well as human SH-SY5Y neuroblastoma cell line glucose deprivation model

[201]

Anti-apoptotic effects demonstrated in vitro in:

 Undifferentiated P19 neuronal cell line model of NMDA-induced apoptosis

[202]

 PC12 rat pheochromocytoma cell line model of serum deprivation-induced apoptosis in adrenal medulla cells

[203]

 Primary rat embryonic cultured neural precursor cell model investigating the effect of DHEA and DHEAS on Akt phosphorylation

[204]

 Primary rat cerebellar granule cell model of hypoxia and glucose deprivation

[205]

Anti-glucocorticoid effects demonstrated both in vitro and in vivo in:

 Primary rat embryonic hippocampal neurons exposed to neurotoxic doses of corticosterone

[206]

 HT-22mouse hippocampal cell line model of glutamate and amyloid-β-induced neurotoxicity

[188]

 Mitigating effects on corticosterone-induced suppression of neurogenesis and survival of new neurons in dentate gyri (hippocampi) of Lister Hooded Rats

[207]

 Inhibitory effects of DHEA on glucocorticoid amplification in 3 T3-L1 adipocyte cell line and C57BL/6J mouse white adipose and liver tissue

[208]

 Inhibition of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) mediated conversion of cortisol by DHEA metabolites in human skin samples

[209]

 Suppression of 11β-HSD1 mRNA in HEK-293 rat cortical collecting duct cell line, as well as kidneys of C57BL/6J mice and Sprague–Dawley rats

[210]