New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis

Liu, Wen-Tong; Lv, Yu-Jin; Yang, Rui-Cheng; Fu, Ji-Yang; Liu, Lu; Wang, Huan; Cao, Qi; Tan, Chen; Chen, Huan-Chun; Wang, Xiang-Ru

doi:10.1186/s12974-018-1325-z

Journal of Neuroinflammation

Table 3 Significantly changed proteins in PCN033-infected hBMECs

From: New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis

Accession	Description	MW [kDa]	Fold change	P value^a
A6ZKI3	Protein FAM127A	13.2	0.756	0.028947*
O00625	Pirin	32.1	1.228	0.037445*
O43633	Charged multivesicular body protein 2a	25.1	0.758	0.002376**
O43752	Syntaxin-6	29.2	0.79	0.025619*
O60524	Nuclear export mediator factor NEMF	122.9	0.83	0.004194**
O75190	DnaJ homolog subfamily B member 6	36.1	0.799	0.020038*
O75251	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	23.5	0.711	0.004822**
O75817	Ribonuclease P protein subunit p20	15.6	0.815	0.017814*
O95229	ZW10 interactor	31.3	0.668	0.003727**
P04004	Vitronectin	54.3	0.808	0.003548**
P07305	Histone H1.0	20.9	0.776	0.008176**
P11532	Dystrophin	426.5	0.691	0.003088**
P14174	Macrophage migration inhibitory factor	12.5	1.486	0.000377***
P16401	Histone H1.5	22.6	0.631	0.000673***
P16402	Histone H1.3	22.3	0.6	0.000896***
P16403	Histone H1.2	21.4	0.572	7.57E−05***
P35251	Replication factor C subunit 1	128.2	0.786	0.013936*
P35527	Keratin, type I cytoskeletal 9	62	0.72	0.001431**
P39060	Collagen alpha-1(XVIII) chain	178.1	0.792	0.031694*
P46013	Antigen KI-67	358.5	0.793	0.005934**
P48651	Phosphatidylserine synthase 1	55.5	0.83	0.000234***
P49585	Choline-phosphate cytidylyltransferase A	41.7	0.608	0.002306**
P50914	60S ribosomal protein L14	23.4	0.71	0.005946**
P52756	RNA-binding protein 5	92.1	0.758	0.005815**
P56377	AP-1 complex subunit sigma-2	18.6	0.765	2.4E−06***
P61966	AP-1 complex subunit sigma-1A	18.7	0.814	4.81E−08***
P62277	40S ribosomal protein S13	17.2	0.792	0.002441**
P62380	TATA box-binding protein-like protein 1	20.9	0.621	0.000503***
Q13625	Apoptosis-stimulating of p53 protein 2	125.5	0.724	0.006481**
Q14241	Transcription elongation factor B polypeptide 3	89.9	0.647	0.006556**
Q14686	Nuclear receptor coactivator 6	219	0.792	0.005234**
Q15388	Mitochondrial import receptor subunit TOM20 homolog	16.3	0.823	0.007395**
Q15629	Translocating chain-associated membrane protein 1	43	0.809	0.023084*
Q17RN3	Protein FAM98C	37.3	0.821	0.010317*
Q4V339	COBW domain-containing protein 6	43.9	0.747	1.2E−05***
Q567U6	Coiled-coil domain-containing protein 93	73.2	0.814	0.001351**
Q5SSJ5	Heterochromatin protein 1-binding protein 3	61.2	0.828	0.000364***
Q6N069	N-alpha-acetyltransferase 16, NatA auxiliary subunit	101.4	0.775	0.001734**
Q709C8	Vacuolar protein sorting-associated protein 13C	422.1	0.799	0.000576***
Q7Z422	SUZ domain-containing protein 1	17	0.808	0.002542**
Q8IXJ9	Putative Polycomb group protein ASXL1	165.3	0.807	0.007037**
Q8N2K0	Monoacylglycerol lipase ABHD12	45.1	0.786	0.0034**
Q8N884	Cyclic GMP-AMP synthase	58.8	0.82	0.013058*
Q8NC44	Protein FAM134A	57.8	0.78	0.010814*
Q8NC60	Nitric oxide-associated protein 1	78.4	0.81	0.013637*
Q8NEY1	Neuron navigator 1	202.3	0.797	0.020924*
Q8TEM1	Nuclear pore membrane glycoprotein 210	205	0.833	0.032212*
Q8WUP2	Filamin-binding LIM protein 1	40.6	0.809	0.002633**
Q8WVV9	Heterogeneous nuclear ribonucleoprotein L-like	60	0.804	0.013638*
Q8WXA3	RUN and FYVE domain-containing protein 2	75	0.744	0.041934*
Q92604	Acyl-CoA:lysophosphatidylglycerol acyltransferase 1	43.1	0.789	0.033787 *
Q96A57	Transmembrane protein 230	13.2	0.786	0.000449***
Q96LB3	Intraflagellar transport protein 74 homolog	69.2	0.543	2.53E−05***
Q96RU3	Formin-binding protein 1	71.3	0.679	2.07E−05***
Q96T37	Putative RNA-binding protein 15	107.1	0.728	0.024086*
Q9GZP8	Immortalization upregulated protein	10.9	1.207	0.032624*
Q9H074	Polyadenylate-binding protein-interacting protein 1	53.5	1.266	0.004395**
Q9H5N1	Rab GTPase-binding effector protein 2	63.5	0.77	0.001156**
Q9H5X1	MIP18 family protein FAM96A	18.3	0.8	0.000118***
Q9HB40	Retinoid-inducible serine carboxypeptidase	50.8	1.215	0.000733***
Q9HC52	Chromobox protein homolog 8	43.4	1.201	0.023152*
Q9NPD3	Exosome complex component RRP41	26.4	0.759	0.000746***
Q9NRY4	Rho GTPase-activating protein 35	170.4	0.792	0.011172*
Q9NS87	Kinesin-like protein KIF15	160.1	0.785	0.010039*
Q9NSP4	Centromere protein M	19.7	0.802	0.021316*
Q9NTI5	Sister chromatid cohesion protein PDS5 homolog B	164.6	0.826	0.003399**
Q9NWU5	39S ribosomal protein L22, mitochondrial	23.6	0.812	0.016677*
Q9NZQ3	NCK-interacting protein with SH3 domain	78.9	0.661	0.00317**
Q9P0V3	SH3 domain-binding protein 4	107.4	0.797	0.001833**
Q9UBL6	Copine-7	70.2	0.823	2.73E−05***
Q9UJW0	Dynactin subunit 4	52.3	0.823	0.012604*
Q9UNP9	Peptidyl-prolyl cis-trans isomerase E	33.4	0.75	0.044207*
Q9Y2R0	Cytochrome c oxidase assembly protein 3 homolog, mitochondrial	11.7	0.792	0.003694**
Q9Y5Y2	Cytosolic Fe-S cluster assembly factor NUBP2	28.8	0.787	0.000891***
Q9Y6I9	Testis-expressed sequence 264 protein	34.2	0.814	0.047637*
Q9Y3Y2	Chromatin target of PRMT1 protein	26.4	0.828	0.008622**
Q9Y4R8	Telomere length regulation protein TEL2 homolog	91.7	0.735	0.013443*
P10412	Histone H1.4	21.9	0.655	0.001429**

^aP < 0.05 (*) was considered significant, and P < 0.01 (**), as well as < 0.001 (***), were all considered extremely significant

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ISSN: 1742-2094

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