Table 1 Characteristics of the hip fracture and medical delirium patients
From: CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau
Hip fracture cohort | Medical delirium | |||||
|---|---|---|---|---|---|---|
All | No delirium | Delirium | ||||
All | Incident | Prevalent | Medical | |||
PATIENTS WITHOUT DEMENTIA | ||||||
N | 59 | 44 | 15 | 7 | 8 | 17 |
Age (years) | 84 (10) | 84 (16) | 85 (7) | 86 (11) | 85 (7) | 66 (16) |
Gender | ||||||
Male | 17 | 11 | 6 | 3 | 3 | 10 |
Female | 42 | 33 | 9 | 4 | 5 | 7 |
Time to surgery (h)* | 23 (17) | 23 (17) | 27 (15) | 22 (19) | 30 (14) | – |
CSF sTREM2 ng/ml | 7.8 (5.7) | 7.4 (5) | 11.1(11) | 11.6 (5) | 7.8 (15) | 5.6 (8) |
CSF biomarkers | ||||||
N | 57 | 44 | 13 | 5 | 8 | |
CSF Aβ42 (pg/ml) | 446 (367) | 479 (414) | 283 (224) | 283 (232) | 295 (253) | – |
CSF t-tau (pg/ml) | 369 (276) | 356 (198) | 564 (638) | 564 (369) | 587 (795) | – |
CSF p-tau (pg/ml) | 57(35) | 54 (33) | 78 (68) | 78 (19) | 88 (89) | – |
CSF Aβ42 cut-off (< 530 pg/ml) | ||||||
Below | 37 | 26 | 11 | 4 | 7 | – |
Above | 20 | 18 | 2 | 1 | 1 | – |
CSF p-tau cut-off (≥ 60 pg/ml) | ||||||
Above | 26 | 17 | 9 | 4 | 5 | – |
Below | 31 | 27 | 4 | 1 | 3 | – |
CSF t-tau cut-off (> 350 pg/ml) | ||||||
Above | 32 | 23 | 9 | 5 | 4 | – |
Below | 25 | 21 | 4 | – | 4 | – |
PATIENTS WITH DEMENTIA | ||||||
N | 61 | 10 | 50 | 13 | 33 | 9 |
Age (years) | 86 (9) | 86.5 (17) | 85(9) | 87 (8) | 85 (8) | 71(23) |
Gender | ||||||
Male | 16 | 1 | 15 | 5 | 8 | 6 |
Female | 45 | 9 | 35 | 8 | 25 | 3 |
Time to surgery (h)* | 26 (28) | 27 (16) | 26(31) | 18(19) | 38 (24) | – |
CSF sTREM2 ng/ml | 7.0 (7.8) | 9.2 (16) | 7.3 (7) | 6.1 (10) | 8.5 (8) | 6.9(6.7) |
CSF biomarkers, N | 60 | 9 | 50 | 13 | 33 | |
CSF Aβ42 (pg/ml) | 265 (166) | 317 (290) | 258 (172) | 268 (219) | 269 (174) | – |
CSF t-tau (pg/ml) | 408 (379) | 441 (503) | 408 (366) | 385 (293) | 407 (329) | – |
CSF p-tau (pg/ml | 55 (41) | 58 (57) | 55 (35) | 55 (47) | 55 (31) | – |
CSF Aβ42 cut-off (< 530 pg/ml) | ||||||
Below | 55 | 7 | 47 | 11 | 1 | – |
Above | 5 | 2 | 3 | 2 | 32 | – |
CSF p-tau cut-off (≥ 60 pg/ml) | ||||||
Above | 24 | 4 | 20 | 5 | 13 | – |
Below | 36 | 5 | 30 | 8 | 20 | – |
CSF t-tau cut-off (> 350 pg/ml) | ||||||
Above | 38 | 5 | 33 | 8 | 22 | – |
Below | 22 | 4 | 17 | 5 | 11 | – |