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Table 1 Characteristics of the hip fracture and medical delirium patients

From: CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau

  Hip fracture cohort Medical delirium
All No delirium Delirium
All Incident Prevalent Medical
PATIENTS WITHOUT DEMENTIA
N 59 44 15 7 8 17
Age (years) 84 (10) 84 (16) 85 (7) 86 (11) 85 (7) 66 (16)
Gender
 Male 17 11 6 3 3 10
 Female 42 33 9 4 5 7
Time to surgery (h)* 23 (17) 23 (17) 27 (15) 22 (19) 30 (14)
CSF sTREM2 ng/ml 7.8 (5.7) 7.4 (5) 11.1(11) 11.6 (5) 7.8 (15) 5.6 (8)
CSF biomarkers
N 57 44 13 5 8  
CSF Aβ42 (pg/ml) 446 (367) 479 (414) 283 (224) 283 (232) 295 (253)
CSF t-tau (pg/ml) 369 (276) 356 (198) 564 (638) 564 (369) 587 (795)
CSF p-tau (pg/ml) 57(35) 54 (33) 78 (68) 78 (19) 88 (89)
CSF Aβ42 cut-off (< 530 pg/ml)
 Below 37 26 11 4 7
 Above 20 18 2 1 1
CSF p-tau cut-off (≥ 60 pg/ml)      
 Above 26 17 9 4 5
 Below 31 27 4 1 3
CSF t-tau cut-off (> 350 pg/ml)      
 Above 32 23 9 5 4
 Below 25 21 4 4
PATIENTS WITH DEMENTIA
N 61 10 50 13 33 9
Age (years) 86 (9) 86.5 (17) 85(9) 87 (8) 85 (8) 71(23)
Gender
 Male 16 1 15 5 8 6
 Female 45 9 35 8 25 3
Time to surgery (h)* 26 (28) 27 (16) 26(31) 18(19) 38 (24)
CSF sTREM2 ng/ml 7.0 (7.8) 9.2 (16) 7.3 (7) 6.1 (10) 8.5 (8) 6.9(6.7)
CSF biomarkers, N 60 9 50 13 33  
CSF Aβ42 (pg/ml) 265 (166) 317 (290) 258 (172) 268 (219) 269 (174)
CSF t-tau (pg/ml) 408 (379) 441 (503) 408 (366) 385 (293) 407 (329)
CSF p-tau (pg/ml 55 (41) 58 (57) 55 (35) 55 (47) 55 (31)
CSF Aβ42 cut-off (< 530 pg/ml)
 Below 55 7 47 11 1
 Above 5 2 3 2 32
CSF p-tau cut-off (≥ 60 pg/ml)      
 Above 24 4 20 5 13
 Below 36 5 30 8 20
CSF t-tau cut-off (> 350 pg/ml)      
 Above 38 5 33 8 22
 Below 22 4 17 5 11
  1. Data are presented as median and interquartile range (IQR), waiting time for surgery. Aβ42, amyloid beta 1–42; t-tau, total-tau; p-tau, phosphorylated tau; sTREM2, soluble triggering receptor expressed on myeloid cells
  2. *Time to surgery, hours from hospital admission to surgery (onset of anesthesia) and CSF sampling