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Table 2 CSF sTREM2 Spearman’s Rho correlations in the hip fracture cohort

From: CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau

  PATIENTS WITHOUT DEMENTIA PATIENTS WITH DEMENTIA
  All No delirium Delirium All No delirium Delirium
N 59 44 15 61 (60) 10 50
  Rho p Rho p Rho p Rho p Rho p Rho p
Age 0.21 0.12 0.12 0.43 0.23 0.40 0.00 0.98 0.16 0.66 -0.05 0.74
Time to surgery (hours) * 0.01 0.93 -0.03 0.83 0.06 0.84 0.39 0.002 0.43 0.21 0.40 0.005
CSF Biomarkers
N 57   44   13   60   9   50  
  Rho p Rho p Rho p Rho p Rho p Rho p
CSF Aβ42 (pg/ml) 0.11 0.40 0.20 0.18 0.31 0.30 0.40 0.002 0.02 0.97 0.53 <0.001
CSF Aβ38 (pg/ml) MSD 0.09 0.49 0.06 0.71 0.18 0.55 0.44 <0.001 0.40 0.29 0.45 0.001
CSF Aβ40 (pg/ml) MSD 0.14 0.32 0.12 0.44 0.23 0.45 0.48 <0.001 0.37 0.33 0.51 <0.001
CSF Aβ42 (pg/ml) MSD 0.09 0.52 0.24 0.12 -0.13 0.67 0.43 0.001 0.15 0.70 0.53 <0.001
CSF t-tau (pg/ml) 0.14 0.28 -0.04 0.82 0.20 0.51 0.46 <0.001 0.83 0.005 0.34 0.016
CSF p-tau (pg/ml) 0.12 0.38 -0.02 0.90 0.23 0.46 0.49 <0.001 0.77 0.016 0.37 0.008
  1. Aβ42, amyloid beta 1–42; t-tau, total-tau; p-tau, phosphorylated tau; sTREM2, soluble triggering receptor expressed on myeloid cells
  2. *Time to surgery, hours from hospital admission to surgery (onset of anesthesia) and CSF sampling