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Table 1 Clinical features of patients with recurrent isolated optic neuritis divided according to the subcriteria of chronic relapsing inflammatory optic neuropathy

From: Chronic relapsing inflammatory optic neuropathy (CRION): a manifestation of myelin oligodendrocyte glycoprotein antibodies

Patient no. Sex/age at onset Criteria for CRION MOG-IgG assay results Brain lesion on MRI
Relapsing optic neuritis Loss of visual function Negative for AQP4-Ab assay Contrast enhancement of the optic nerve on MRI Response to steroid treatment Relapse on withdrawal or dose reduction of steroid treatment
1 M/46 Yes Yes Yes Yes Yes Yes Positive No
2 F/62 Yes Yes Yes Yes Yes Yes Positive No
3 F/52 Yes Yes Yes Yes Yes Yes Positive No
4 M/52 Yes Yes Yes Yes Yes Yes Positive Nonspecific white matter abnormality
5 M/38 Yes Yes Yes Yes Yes Yes Positive No
6 F/32 Yes Yes Yes Yes Yes Yes Positive No
7 F/20 Yes Yes Yes Yes Yes Yes Positive Brain stem lesion
8 F/23 Yes Yes Yes Yes Yes Yes Positive No
9 F/51 Yes Yes Yes Yes Yes Yes Positive No
10 F/39 Yes Yes Yes Yes Yes Yes Positive No
11 M/41 Yes Yes Yes Yes Yes Yes Positive Asymptomatic focal T2 high signal intensity in the pontine tegmentum
12 F/54 Yes Yes Yes Yes Yes Yes Borderline No
13 F/10 Yes Yes Yes Yes Yes No Negative No
14 F/57 Yes Yes Yes Yes Yes No Negative No
15 F/73 Yes Yes Yes Yes Yes No Negative Nonspecific white matter abnormality
16 F/33 Yes Yes Yes Yes Yes No Negative No
17 F/57 Yes Yes Yes Yes Yes No Negative Nonspecific white matter abnormality
18 F/27 Yes Yes Yes Yes Yes No Negative No
19 F/55 Yes Yes Yes Yes No No Negative Nonspecific white matter abnormality
20 F/46 Yes Yes Yes No No No Negative Nonspecific white matter abnormality
21 F/53 Yes Yes Yes No No No Negative No
22 F/40 Yes Yes Yes No No No Negative No
23 F/28 Yes Yes Yes No No No Negative Asymptomatic focal right frontal white matter lesion
24 F/34 Yes Yes Yes No Yes No Negative No
25 M/20 Yes Yes Yes No Yes No Negative No
26 F/57 Yes Yes Yes No No No Negative Nonspecific white matter abnormality