Table 1 Clinical features of patients with recurrent isolated optic neuritis divided according to the subcriteria of chronic relapsing inflammatory optic neuropathy
Patient no. | Sex/age at onset | Criteria for CRION | MOG-IgG assay results | Brain lesion on MRI | |||||
|---|---|---|---|---|---|---|---|---|---|
Relapsing optic neuritis | Loss of visual function | Negative for AQP4-Ab assay | Contrast enhancement of the optic nerve on MRI | Response to steroid treatment | Relapse on withdrawal or dose reduction of steroid treatment | ||||
1 | M/46 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | No |
2 | F/62 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | No |
3 | F/52 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | No |
4 | M/52 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | Nonspecific white matter abnormality |
5 | M/38 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | No |
6 | F/32 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | No |
7 | F/20 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | Brain stem lesion |
8 | F/23 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | No |
9 | F/51 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | No |
10 | F/39 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | No |
11 | M/41 | Yes | Yes | Yes | Yes | Yes | Yes | Positive | Asymptomatic focal T2 high signal intensity in the pontine tegmentum |
12 | F/54 | Yes | Yes | Yes | Yes | Yes | Yes | Borderline | No |
13 | F/10 | Yes | Yes | Yes | Yes | Yes | No | Negative | No |
14 | F/57 | Yes | Yes | Yes | Yes | Yes | No | Negative | No |
15 | F/73 | Yes | Yes | Yes | Yes | Yes | No | Negative | Nonspecific white matter abnormality |
16 | F/33 | Yes | Yes | Yes | Yes | Yes | No | Negative | No |
17 | F/57 | Yes | Yes | Yes | Yes | Yes | No | Negative | Nonspecific white matter abnormality |
18 | F/27 | Yes | Yes | Yes | Yes | Yes | No | Negative | No |
19 | F/55 | Yes | Yes | Yes | Yes | No | No | Negative | Nonspecific white matter abnormality |
20 | F/46 | Yes | Yes | Yes | No | No | No | Negative | Nonspecific white matter abnormality |
21 | F/53 | Yes | Yes | Yes | No | No | No | Negative | No |
22 | F/40 | Yes | Yes | Yes | No | No | No | Negative | No |
23 | F/28 | Yes | Yes | Yes | No | No | No | Negative | Asymptomatic focal right frontal white matter lesion |
24 | F/34 | Yes | Yes | Yes | No | Yes | No | Negative | No |
25 | M/20 | Yes | Yes | Yes | No | Yes | No | Negative | No |
26 | F/57 | Yes | Yes | Yes | No | No | No | Negative | Nonspecific white matter abnormality |