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Table 2 Comparison of clinical features in patients with MOG-IgG-positive isolated optic neuritis according to the disease course

From: Chronic relapsing inflammatory optic neuropathy (CRION): a manifestation of myelin oligodendrocyte glycoprotein antibodies

Variables CRION with MOG-IgG (n = 11) Non-CRION with MOG-IgG (n = 11) P value
Age at 1st onset (years) 41.4 ± 12.8 (20.8–62.1) 45 ± 21 (15–70.7) n.s.
Sex (M:F) 4:7 6:5 n.s.
Presence of the serum IgG1 MOG-IgG (n) 11 (100%) 11 (100%) n.s.
Relapsing disease course (n) 11 (100%) 0 < 0.001
Duration of oral immunosuppressive treatment after 1st attack (months) 1.0 ± 1.0 (0–2.8) 2.4 ± 2.8 (0–9.1) n.s.
Unilateral:Bilateral involvement (n) 6:5 6:5 n.s.
Pain with eye movement (n) 9 (82%) 8 (73%) n.s.
Optic disc swelling (n) 3/9 (33%) 7 (64%) n.s.
Visual acuity at nadir (logMAR) 1.5 ± 0.9 (0–2.6) 1.3 ± 1 (0–2.3) n.s.
Visual acuity less than 20/200 at nadir (n) 8/10 (80%) 5/10 (50%) n.s.
Enhancement of optic nerve on MRI (n) 11 (100%) 10/10 (100%) n.s.
Perineural enhancement of optic nerve on MRI (n) 5/7 (71%) 6/10 (60%) n.s.
Anatomical segment of optic nerve enhancement
 Proportion in orbital area (%) 70.0 ± 26 (30–100) 69.5 ± 30 (20–100) n.s.
 Orbital (n) 9/9 (100%) 10/10 (100%) n.s.
 Canalicular (n) 3/9 (33%) 4/10 (40%) n.s.
 Intracranial (n) 2/9 (22%) 0/10 (0%) n.s.
 Chiasmal (n) 1/9 (11%) 0/10 (0%) n.s.
Pattern of visual field defect at first attack (n)
 Central 5 (45%) 5 (46%) n.s.
 Altitudinal 1 (10%) 3 (27%) n.s.
 Diffuse 5 (45%) 3 (27%) n.s.
Total follow-up duration (months) 45.7 ± 25.8 (5.8–104.5) 42.6 ± 31.8 (9.1–95.8) n.s.
Total number of attacks (n) 4.1 ± 1.8 (2–7) 1 ± 0 (1–1) < 0.001
Time interval between 1st and 2nd attack (months) 2.3 ± 2.2 (0.4–7)
Frequency (total number of attacks/years) 1.7 ± 1.6 (0.3–6.2) 0.6 ± 0.6 (0.1–2.1) 0.023
Visual acuity at final follow-up (logMAR) 0.2 ± 0.7 (−0.1–2.3) 0 ± 0.1 (−0.2–0.2) n.s.
Visual acuity more than 20/40 at final follow-up 10/11 (91%) 9/9 (100%) n.s.
Retinal nerve fiber layer thickness (μm)
 Average 65.7 ± 11.5 (50–81) 83.3 ± 12.5 (69–92) 0.040
 Superior 80.7 ± 21.1 (52–107) 107.7 ± 24.9 (79–124) n.s.
 Temporal 43.7 ± 8.7 (33–55) 60.3 ± 1.5 (59–62) 0.001
 Inferior 81.5 ± 21.8 (51–114) 99 ± 24.8 (71–118) n.s.
 Nasal 60.3 ± 9.0 (46–77) 70 ± 7.8 (65–79) n.s.
Ganglion cell-inner plexiform layer thickness (μm)
 Average 64.4 ± 6.5 (52–72) 76 ± 5.6 (71–82) 0.002
 Minimum 59.3 ± 7.0 (45–70) 68.7 ± 9 (60–78) 0.006
Central macular layer thickness (μm) 242.5 ± 21.2 (215–282) 237.3 ± 22.9 (207–248) n.s.
  1. Abbreviations: MOG-IgG myelin oligodendrocyte glycoprotein immunoglobulin G, CRION chronic relapsing inflammatory optic neuropathy, ON optic neuritis