Fig. 5

EZH2 expression in the CNS of EAE and multiple sclerosis patients. a Graphs showing expression levels for EZH2 and Cd3 in spinal cord from EAE mice (black bars) and control mice (open bars). The x-axis indicates days post-immunization (d) and number of EAE and control mice per group. b Boxplots showing the percentage of CD3+ T cells and CD56dim NK cells expressing EZH2 in the CSF and peripheral blood compartments of multiple sclerosis patients (n = 3 for CSF; n = 10 for blood). c Expression of EZH2 in CD4+ and CD8+ T cells from chronic active lesions of multiple sclerosis patients (N = 10). Arrows indicate CD4+ or CD8+ T cells expressing EZH2. Graph shows the percentage of CD4+ and CD8+ T cells expressing EZH2 in CNS lesions. Bars represent mean (standard error of the mean). Statistics: a unpaired Student’s t test; b Mann-Whitney U test. *p values < 0.05; **p values < 0.01; ***p values < 0.001. EZH2, enhancer of zeste 2 polycomb repressive complex 2 subunit; Cd3 Cd3e, CD3 antigen, epsilon polypeptide