Fig. 2
From: Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice
a, b LPS challenge dramatically changes the morphology of microglia and induces the activation of the NF-κB pathway (e, f, and i). c, d, g–i Ibuprofen did not block the activation of microglia after LPS stimulation. j–o Both annexin V and PI signals accumulated in neuronal culture when treated with LM. Ibuprofen pretreatment significantly blocked both apoptotic and necrotic processes. Scale bar = 50 μm. n = 4 for each group. ** p < 0.01, *** p < 0.001, **** p < 0.0001