Fig. 1

Metabolic outcomes associated with diet-induced obesity in mice treated with vehicle (Veh) or the TLR4 inhibitor TAK-242 (TAK). a Body weights in male C57BL6/J mice maintained on control (CTL) and high-fat (HFD) diets and vehicle (Veh) and TAK-242 (TAK) treatments taken at baseline (week 0) and 4-week intervals across the 12-week experimental period, and b body weights at the end of the treatment period. c Lean mass and d percent body fat via NMR scan. e, f Adiposity as measured by e retroperitoneal (RP) fat pad and f gonadal fat pad weights. g Average daily caloric intake across the experimental period. Data are presented as mean (±SEM) values; n = 10–14/group. For data presented across time, control diet-fed mice are shown as circles, high-fat diet-fed mice are shown as squares; vehicle-treated are open symbols, TAK-242-treated are filled symbols; for all other panels, vehicle-treated animals are shown in white bars and TAK-242-treated are shown in black bars. Statistical significance is based on ANOVA followed by Bonferroni correction. * p < 0.05 relative to drug treatment-matched mice in control diet condition